Despite advances in regulations and initiatives to increase pediatric medicine development,\nthere is still an unmet need for age-appropriate medicines for children. The availability of pediatric\nformulations is particularly lacking in resource poor areas, due to, for example, area-specific disease\nburden and financial constraints, as well as disconnected supply chains and fragmented healthcare\nsystems. The paucity of authorized pediatric medicines often results in the manipulation and\nadministration of products intended for adults, with an increased risk of mis-dosing and adverse\nreactions. This article provides an overview of the some of the key difficulties associated with the\ndevelopment of pediatric medicines in both high and low resource areas, and highlights shared and\nlocation specific challenges and opportunities. The utilization of dispersible oral dosage forms and\nsuppositories for low and middle-income countries (LMICs) are described in addition to other platform\ntechnologies that may in the future offer opportunities for future pediatric medicine development for\nlow resource settings.
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